by : admin Air Conditioner

Don’t Let Your Commercial Air Conditioner Cost You Business This Season

Whether it is a convenience or grocery store, an apartment complex or a showroom that you are running, your commercial air conditioning system is vital to the successfulness of your business. If it does not work, you may not either. This is not a not a gamble you can afford to take. If it suddenly stops cooling, your employees and customers will be uncomfortable, and neither will be there long.

It is important to have a trusting relationship with a reliable air conditioning company that can maintain, regularly service and inspect your HVAC unit. Having a reputable commercial air conditioning repair contractor in your area who knows your system will make sure it performs optimally, all year round.

It’s never a good idea to wait till your unit stops cooling or quits altogether, so if you do not have a regular commercial AC specialist, or are dissatisfied with your current company, it would be smart to find one right away. When searching, make sure they are experienced with all the commercial brands, like York, Carrier, Mitsubishi and more. Ask pertinent questions, such as:

• How long have they been in business and can they provide references?
• Are they licensed, bonded and insured?
• Do they offer emergency service, even on holidays?
• How much are the service calls?
• Are they prompt? Is there a “window of time” in which they will give you?
• Will the technicians give you a written estimate or a breakdown of parts and labor?
• Are the technicians unobtrusive? Will they clean up the debris after the job is completed?
• Will they show up with the most common parts on board? If they don’t have the necessary parts with them, do they charge another “trip” charge to return?

Your HVAC companies can inspect your unit and be able to tell you if you are getting the best out of your unit, as well as give you tips on how you may be able to get better energy savings.

A professional air conditioning repair person can determine if you have the correctly sized equipment that meets the needs of your business. Factors such as the square footage, the age of the building, how many stories you have, the quality of windows, how well it is insulated, as well as local energy rates. All of these things play a huge part in the money you may be wasting.

A qualified commercial contractor can also spot defective, undersized or oversized equipment as well as leaky ductwork. This goes a long way in bringing those bills down.

Most commercial air conditioning companies will need to perform a maintenance check on your system. This is normally done in the “off” months, the spring and the fall. These bi-yearly tune-ups will ensure that there are no unpleasant surprises during business hours. Having regular maintenance inspections can also quite possibly save you the cost of an emergency repair.

If your commercial unit is more than 10 years old, it probably is not working efficiently, and it may be time to upgrade to a higher energy-efficient system. Older models typically do not work at their full potential and can significantly increase energy bills. Your air conditioning professional can tell you if your HVAC unit is not cooling at peak capacity and can advise you if it is time to replace it. A good portion of the cost of the new commercial unit will be offset by the money you will save when you see the savings on the electric bills.

When you need commercial air conditioning, heating, air conditioning repair, air conditioning systems for home, commercial or industrial use we have what you need. We’ve been in business since 1987 and are committed to delivering value to our clients and customers so they continue to choose us year after year.

by : admin Health Professional

Stuart FL Chiropractors Relieves Pain from Any Type Of Musculoskeletal Problem

The Doctor Of The Future Will Give No Medicine, But Will Interest His Patients In The Care Of The Human Frame, In Diet, And In The Cause And Prevention Of Disease………..Thomas Edison.

These words of Thomas Edison has become so true, because people nowadays are preferring treatment through chiropractic cure, diets and exercises than medicines. In chiropractic treatment, the chiropractors do not treat disease alone that is treated but the root cause of the disease is located and treated, so that the patient is completely cured.

There are so many diseases that can be cured without medications, through proper chiropractic treatments. There are chiropractic cure for back pain, migraine and headaches, arthritis, neck pain, shoulder pain etc. Chiropractors can help to relieve pain from any type of musculoskeletal problems. If you are looking around for chiropractic physical therapy in Stuart, then you can find some of the best Stuart FL Chiropractors.

Chiropractor Stuart Fl will help you to relieve pain through drug free treatments. The Stuart FL chiropractic doctors are experts in the field of spinal health care and he deals with all problems concerned with the spine and spinal deformation. There are trained and experienced to perform all types of chiropractic techniques.

Chiropractors Stuart FL not only understands the symptoms, but the main reason for the illness so that the pain can be totally removed. All chiropractors rely on hands-on approach other than drugs and surgery. The whole body gets affected, if the function of the spine gets affected, and the chiropractors rectify the problem of the spine, to improve the overall wellness of the patient. Spine manipulation is the approach that chiropractors practice. The chiropractic treatment might be a little painful for patients who are experiencing it the first time. But after a few sittings, the patients not only get relief from pain, but get better sleep and more energy. Chiropractic treatments improve posture and overall health and it is said that it even reduces the aging process. Chiropractic treatment also benefits pregnant ladies by helping them to deliver easily and faster.

Sometimes neck pain can be due to severe stress. Emotional stress can affect the function of your body making your body more susceptible to pain and neck pain is the result of this stress. The Stuart FL chiropractor helps you to relax and reduce stress by keeping your spine and nervous system in optimal working condition, so that you can handle any type of tensions and stress. Impairment of your nervous system can cause problems in your muscles, joints and bones and this can be directly related to spinal problems, and chiropractic care is the most recommended for this. The internal system of the body is healed to rectify the problem.

When you go to a chiropractor, he will first examine you, diagnose the medical condition you are suffering from and then decide the type of chiropractic care needed. There are three types of chiropractic care. When a patient is suffering from acute pain, then it is treated through Chiropractic Care – Relief; long term spinal problem without proper treatment is treated through Corrective Chiropractic care and the treated spine is maintained through Maintenance Chiropractic Care. Chiropractic care is gentle and safe and helps the patient to get relief from pain before it worsens. There are quite a number of chiropractic clinics in Stuart and if you are looking for better health through the finest quality chiropractic care, then choose Wiedner Family Chiropractic, who are dedicated to helping families achieve optimal health for life.

A study in 1990 has proved that the most effective treatment for back pain is chiropractic therapy.  Chiropractic therapy treats colic pain in children and also helps to reduce blood pressure and helps digestive disorder.

At Wiedner Family Chiropractic we are dedicated to helping families achieve Optimal Health for life! Combining the skills and expertise of chiropractic corrective and wellness care, Wiedner Chiropractor Dr. William Wiedner and the Wiedner Family Chiropractic team are committed to bringing Stuart, FL better health naturally by teaching and practicing the true principles of chiropractic.

by : admin Medicine

Chemokines play vital roles in inflammation and cancer

Chemokines are a superfamily of small secreted peptides. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. The major role of chemokines is to act as a chemoattractant to guide the migration of cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. The chemokine family currently includes some 45 human ligands and 19 receptors, although this list may grow as more chemokine/receptor like candidate genes exist in the human genome. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.

Chemokine receptors belong to G-protein-coupled receptors. However, cells can only respond to a chemokine in a given organ or tissue if the cell possesses a receptor that specifically recognizes the chemokine that is present in the local environment. In this way, each chemokine-chemokine receptor combination may direct a different inflammatory response and this response can be tailored by the body based on the type of injury, irritation, or other threat. Different chemokines are made in different tissues at different times and different chemokine receptors are expressed on the surface of different types of inflammatory cells. Chemokines and other chemoattractants direct inflammatory responses by serving to precisely coordinate the movement of cells of the immune system. Inappropriate activity of the chemokine network is at the core of numerous autoimmune and inflammatory conditions. For example, in Crohn’s disease, dysregulation of either the chemokine CCL25 or the chemokine receptor to which it binds, CCR9, is thought to selectively attract inflammatory T cells to, and subsequently attack, tissues in the digestive tract.

Originally studied because of their role in inflammation, chemokines and their receptors are now known to play a crucial part in directing the movement of mononuclear cells throughout the body, engendering the adaptive immune response and contributing to the pathogenesis of a variety of diseases. Many chemokine/receptor pairs are expressed in tumours, not only by cancer cells but also by cells of the tumour microenvironment, including cells of the stroma (endothelial cells, fibroblasts) and leukocytes, thus contributing to the cross-talk between the tumour and its microenvironment to control tumour growth and progression. The interaction of chemokines, their receptors, growth factors, inflammatory with cancer cells forms a complex network at the tumour site, responsible for the overall progression or rejection of the tumour.  In the malignancy context, chemokines play diverse effects, most of them deriving from their ability to induce cell migration. The ability of chemokines to enhance the motility of leukocytes, endothelial cells, and/or tumour cells is a key factor in determining the cancer establishment and progression. Depending on their specific expression pattern on target cells, on tumour type and on tumour microenvironment factors, several chemokines support malignancy, while others can at times inhibit this process. On the basis of these evidences, the characterization of the different chemokine networks in various types of cancer cells may foster better knowledge for understanding the immune-related mechanisms of cancer development and application in cancer immunotherapy.

Chemokines have potential as therapeutic agents in several ways. One can use modified antagonists of the proteins themselves or of their N-termini; use monoclonal antibodies directed either to a specific chemokine or to its receptor; and use small molecules that inhibit their receptors. Current knowledge of chemokine biology should propel the field toward a better understanding of the contribution that chemokine dysregulation makes to chronic inflammation, excess or impaired angiogenesis, and, equally important but more challenging, their role in pathological wound healing. Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Different chemokines are made in different tissues at different times and different chemokine receptors are expressed on the surface of different types of inflammatory cells. Inappropriate activity of the chemokine network is at the core of numerous autoimmune and inflammatory conditions.